Sister Margie is a character in the Fluffoverse who is a Welsh Nun of the Christalordus Church. She smokes weed and has been caught of killing people "In the name of Lord Yeezus Christ". It is not understood if she is referring to Jesus or Kanye West, but due to her undying love for Kanye, it is understood that Kanye directly told her to.
Sister Margie is also a racist character who has said in the video [MARGIE Q AND A] that she is "not a fan of" Jewish people, probably because of her undying love to Jesus and Kanye west, of which no one knows how started.
She also mentions she got "all her holes stretched" by a 16 year old, which is a weak reference to Brandon Rodgers' video Hall Monitor Helen.